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The Reds need a win at Anfield to maintain their fight for the title but Harry Kane, Song Heung-min and Co will fancy their chances against a Liverpool defence that holds a notoriously high line.
However, Klopp is well aware of Spurs’ threat on the break, underlining their ability as the “best counter-attacking players in the world” under Antonio Conte.
“When you think about how Tottenham wins football games, they're a brilliant football team - up front they have speed like crazy," Klopp told reporters on Friday.
“Harry Kane, what a player. He obviously fits in that idea extremely well, there's a blind understanding between [Tottenham’s forwards]. I'd say it's probably the biggest challenge for protection we've faced for a long time.
“To win a football game, you have to create and be high up the pitch. But when you lose [the ball], you should be immediately around all of them, that's difficult. We have to find a way to keep them calm as often as possible.”
Liverpool go into the game having booked a Champions League final date with Real Madrid, and Klopp is “happy” to get another crack at the side which beat them in the 2018 final after Los Blancos downed Manchester City in spectacular fashion.
“It was strange and unlucky for City but what Madrid did was outstanding,” he continued. “They got through against PSG, Chelsea and City... If you knock out these three teams, you definitely deserve to be in final.
“[The final] will be great. We were not happy that night [in 2018] but that was a while ago. I'm happy to go there and give it a try.”