Harry Kane and Marcus Rashford start for Tottenham and Manchester United respectively in Friday's pivotal Premier League clash between the two clubs.
Spurs striker Kane has not featured since tearing his hamstring in his side's 1-0 defeat to Southampton at the start of the year.
As for Rashford, a back injury sidelined him prior to the coronavirus-enforced break to the season.
However, with a delayed finish to the 2019-20 campaign due to the pandemic, both England internationals are fit again and available for a fixture between teams with Champions League aspirations.
Spurs sit eighth in the table, four points behind their fifth-placed opponents.
Jose Mourinho is also able to select Moussa Sissoko, Son Heung-min and Steven Bergwijn in an attacking Spurs line-up as the Portuguese goes up against his former employers.
His replacement at Old Trafford, Ole Gunnar Solskjaer, has Paul Pogba available again. The Frenchman is among the United substitutes, with Scott McTominay given the nod alongside Bruno Fernandes and Fred in midfield.
But Pogba's compatriot Anthony Martial makes the starting XI, joining Rashford and Daniel James in attack.