Khabib has not fought since famously choking out Conor McGregor in October 2018.
Poirier holds the interim 155lb title after beating featherweight champion Max Holloway, and now bids to make it official by winning the full title.
There were dramatic scenes at the weigh-in as Khabib was forced to strip down to his birthday suit in order to make the cut, and only just in time.
LIVE BLOG: Follow the latest from UFC 242
Officials covered his dignity with a towel before he left to go and rehydrate.
What time will the fight start?
Khabib vs Poirier is expected to start at around 9pm BST (midnight in Abu Dhabi).
What TV channel is it on?
The fight will be shown live on BT Sport Box Office, for a cost of £19.95.
How can I live stream online?
The fight can be watched via the BT Sport website or mobile app, for the same Box Office price.
What are the odds?
Full UFC 242 fight card
Khabib Nurmagomedov vs Dustin Poirier
Edson Barboza vs Paul Felder
Islam Makhachev vs Davi Ramos
Curtis Blaydes vs Shamil Abdurakhimov
Mairbek Taisumov vs Carlos Diego Ferreira
Ottman Azaitar vs Teemu Packalen
Liana Jojua vs Sarah Moras
Zubaira Tukhugov vs Lerone Murphy
Joanne Calderwood vs Andrea Lee
Early Preliminary Card
Belal Muhammad vs Takashi Sato
Nordine Taleb vs Muslim Salikhov
Omari Akhmedov vs Zak Cummings
Don Madge vs Fares Ziam
Please allow a moment for the live blog to load