And Murray and the Cardinals were rewarded for his bravery as they rallied to a sensational 29-23 win in overtime.
Cornerback Byron Murphy's fumble return decided the game, but quarterback Murray had brought Arizona to that point.
Under increased scrutiny this season after signing a five-year, $230.5million contract extension – which initially contained a controversial 'homework' clause – Murray threw for 193 yards and two touchdowns against the Kansas City Chiefs in Week 1 but saw the Cardinals beaten 44-21.
Through two quarters in Week 2, Murray had completed only six passes for 53 yards, thrown an interception and not carried the ball once.
It looked like being another miserable day for the former first overall pick and his team-mates, yet he turned the game on its head.
"I had to take over, had to do whatever it took to win," Murray explained. "That was my mindset."
The fourth-year star threw for 224 yards and a TD, rushing for a further score to put Murphy in a position to win the game.
"That feeling, going into the half where nothing is going right, we've felt that plenty of times since I've been here," Murray said afterwards. "It's an ugly feeling.
"But the grit, the resiliency of this group... the issue with this group is never about playing hard. It's about executing."
The pick of Murray's plays was a two-point conversion when the Cardinals trailed the Raiders 23-13, as the QB scrambled for 20 seconds and 85 yards before reaching the end zone.
"There's so many do-or-die plays, I lost count, where we had to have this stop, had to have this two-point conversion, had to score, had to have the fourth down," coach Kliff Kingsbury said.
"And guys just kept fighting. I mean nobody blinked. At half-time, it was just, 'hey, we got to settle in and do what we do'.
"We played about as bad as you could the first half and didn't play great the second half, but the effort was incredible."
Of Murray, he added: "He's a special talent. You can see when he's able to do his thing, that's what he does, and he had some tremendous plays.
"The numbers may not be great, [but] we don't care about numbers."