James had 48 points, nine assists and eight rebounds in a spectacular performance for the Lakers, who beat the Houston Rockets 140-132 on Monday night at Crypto.com Arena.
Before the game began, Houston's 19-year-old power forward Jabari Smith Jr approached LeBron and said: "Hey, you played against my dad, your first NBA game ever. Sacramento."
An amused James replied: "Why do you do that to me?"
Smith added: "You feel old, don't you?"
Smith's cheeky remarks need a little addendum, as records show his father was in fact an unused bench player in that fixture on October 29, 2003, that saw James drop a game-high 25 points for the Cleveland Cavaliers against the Sacramento Kings to make an immediate impact on the NBA.
James and Smith senior did go head to head in the following season, though, when Smith moved on to the New Jersey Nets.
Asked after Monday's game about playing against both father and son, James laughed off Smith's reminder in an interview with NBA TV.
"Versus dad, man, versus dad! It made me feel old as c**p," James said.
"He said, 'That make you feel old?'. I said, 'Absolutely man'.
"I've had the pleasure and the opportunity to play against a couple of dad and son combinations: Gary Trent and Gary Trent Jr, Kenyon Martin and Kenyon Martin Jr, and now Jabari Smith Jr and Jabari Smith Sr.
"It's been a great ride, these 20 years that I've been able to see a lot of great players come in and come out, so it's always an honour for me."
The Lakers scored 113 points with James on the court and did not have one turnover during that time. It made James the only NBA player in the last 20 years to have his team score 100-plus points with no turnovers with him on the floor in a game.
"After the Dallas game and after the Philly game last night, we just had some heartbreaking losses, and we could have found out better ways to close the game," James said.
"Tonight, we kept our composure, and even when they made a run we kept our composure and executed offensively, made some tough shots and then got some key defensive stops."