James scored 47 points on 18-of-27 shooting from the field with 10 rebounds and nine assists, showing the four-time NBA MVP is evergreen.
The 18-time All-Star scored 16 points in both the second and fourth quarters on his way to a season-high points haul.
The Lakers rallied back from a 15-point deficit before getting the edge in a tight fourth quarter, with James' three-pointer giving them a 103-101 lead which they never surrendered.
James iced the game with a pair of free-throws amid chants of "MVP! MVP!" from the State Farm Arena crowd, who appeared to be willing to switch allegiance for the star on his birthday.
The result improves the Lakers to a 15-21 record, having lost nine of their past 13 games entering the game. The Hawks fell to 17-19 having lost their past three.
Giannis drops another 40-point game
The Bucks trailed 61-50 at half-time, but won the third 39-22 led by Antetokounmpo, who finished the game with 43 points on 14-of-23 shooting with 20 rebounds, five assists and two blocks.
Milwaukee had good contributions off the bench from Bobby Portis with 22 points and 14 rebounds and Joe Ingles with 14 points and 10 assists. Anthony Edwards top scored for the Wolves with 30 points and 10 rebounds.
McCollum hits franchise-record 11 threes
McCollum shot 11-of-16 from beyond the arc in a dazzling display, well supported by Zion Williamson with 36 points on 13-of-19 shooting with five rebounds.