LeBron James scored a game-high 26 points with six rebounds and eight assists, while Anthony Davis excelled with 23 points and 15 rebounds, although he appeared to nurse a back injury late.
Russell Westbrook was solid again off the bench, adding 18 points on 50 per cent shooting with eight rebounds and eight assists. Westbrook scored four points in the final two minutes to see off any Nuggets' challenge.
The Lakers improved their three-point shooting, making 13-of-30 attempts at 43.3 per cent, while they also scored 48 points in the paint, taking advantage of the defensive limitations of the Nuggets' two-time MVP-winning center Nikola Jokic.
Jokic recorded a double-double with 23 points and 14 rebounds while Jamal Murray, who missed the 2021-22 campaign with a ruptured ACL, had his best scoring game of the season with 21 points.
The win ends the Lakers' five-game losing run to start the season. For Denver, the defeat means they are 1-3 on the road this season and 4-3 overall.
The Golden State Warriors had defensive issues again as they suffered back-to-back losses and fell to a 3-4 record after a 128-114 loss to the Detroit Pistons, who ended their own five-game losing run.
Last year's top NBA Draft selection Cade Cunningham was an assist short of a triple-double, contributing 23 points, 10 rebounds and nine assists as the Pistons dominated after quarter-time.
Stephen Curry scored 32 points on 10-of-24 shooting, while Jordan Poole added 30 with Klay Thompson rested. The Warriors, who have given up 120-or-more points in five of their past six games, only made 12-of-39 three-point attempts (31 per cent).
Doncic matches rare Jordan feat
The Slovenian point guard shot 17-of-26 from the field for 44 points with three rebounds and five assists. Doncic scored 30 of his 44 points in the first half.
Top 2022 NBA Draft pick Pablo Banchero failed to reach 20 points for the first time in his career, scoring 18 on six-of-20 shooting for the Magic.