Denver kept the Lakers waiting for their first win of the season with a 110-99 victory at Ball Arena, improving to 3-2.
Los Angeles are languishing at the bottom of the Western Conference but will get another chance to get up and running when they face the Minnesota Timberwolves on Friday.
Lakers superstar James was 8-for-21 shooting, finishing with 19 points, nine assists and seven rebounds.
The four-time NBA champion and MVP is not concerned by posting such low numbers by his high standards.
"I wasn't aggressive enough in a lot of my turnovers," James said. "I was coming off a lot of screens, looking to pass, get guys involved, and I wasn't aggressive enough."
He added: "That's an easy fix for me. I'll be much better on Friday with that. I've done it over and over the course of my career. That's an easy fix. I'm not worried about that."
Lakers head coach Darvin Ham is confident the Los Angeles Lakers will turn the corner.
"We're four games in, it sucks to lose, but having 78 games left, there's plenty of time for us to right the ship, and it starts now," Ham said. "It starts yesterday."
Anthony Davis top scored for the Lakers with 22 points in a game that Russell Westbrook missed due to left-hamstring soreness.
James said of Westbrook's absence: "Russ, definitely dealing with a hamstring. I played with [Dwyane] Wade. And I don't know how, but you just have to be cool with all that.
"You can't force it until that thing is ready to go. You've got to be very conscious of that."