Gabon star Aubameyang took a knock during his team's 3-0 win at Sochaux in the League Cup on Tuesday.
Should he fail to make the XI, former Leicester and Leeds winger Max Gradel is expected to start in his place.
Ivory Coast international Gradel scored six goals in 24 Ligue 1 matches last season after joining from Leeds.
Aubameyang is St Etienne’s top scorer this season with six goals in 10 matches.
St Etienne are fifth in the standings, seven points behind Paris St Germain.
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