Some big NFL names are already out or extremely questionable with Week 4 just a few days away. Teams' top wideouts, running backs and even a few quarterbacks could miss the next slate of games with various ailments.
Here's a brief breakdown of the biggest injuries and their current statuses.
Patriots injuries: QB Mac Jones ruled out with ankle injury
Quarterback Mac Jones is one of three New England Patriots players ruled out in the injury report released on Friday. Jones sustained a reported high ankle sprain and was in obvious pain following the Week 3 loss.
ESPN's Adam Schefter reported he could miss "multiple games," but as recently as Thursday Jones appeared optimistic. He was "participating in game planning" and "told multiple teammates not to count him out" for the game, per NFL Network's Mike Giardi.
The Patriots will turn to 14-year veteran Brian Hoyer. Hoyer has lost his last 11 starts dating back to 2016.
Chargers injuries: WR Keenan Allen ruled out for third straight game
Wide receiver Keenan Allen will not play against the Texans in Week 4, which will be his third missed game of the young season. Allen was a limited participant in practice early in the week and has been ruled out. Center Corey Linsley (knee) and tight end Donald Parham Jr. (hamstring) are listed as questionable.
Allen,30, exited practice on Thursday alongside a trainer. He sustained the hamstring injury in the Week 1 win over the Las Vegas Raiders. He had largely been reliable for the Chargers in previous seasons, playing in 16 games four of the past five years.
Lions injuries: WR Amon-Ra St. Brown ruled out, D'Andre Swift 'unlikely' to play
Detroit Lions head coach Dan Campbell ruled out wide receiver Amon-Ra St. Brown for Week 4 on Friday after St. Brown suffered an ankle in Week 3 against the Minnesota Vikings. St. Brown told reporters Thursday he wasn't sure if he'd be able to play against the Seattle Seahawks this weekend.
"It definitely was hurting out there on Sunday," St. Brown said regarding his injury. "Like I said, I never really dealt with a sprained ankle, but when I was cutting and stuff, it was definitely hurting but I just pushed through. The adrenaline definitely helped a bit, but I had to push through and finish that game."
It's a big loss for a Lions offense that looks like it'll be without running back D'Andre Swift as well, who missed Thursday's practice with ankle and shoulder injuries.
Saints injuries: WR Michael Thomas out, QB Jameis Winston doubtful
The Saints already ruled out receiver Michael Thomas for Week 4 in London against the Minnesota Vikings with a foot injury after he didn't practice all week. Winston, meanwhile, missed three straight days of practice time this week with back and ankle injuries. Backup Andy Dalton will likely start against Minnesota Vikings in London on Sunday morning.
Running back Alvin Kamara was limited all week with a rib injury but is questionable for the game.
Buccaneers injuries: WR Chris Godwin is a game-time decision
The Buccaneers could be without Chris Godwin for a third consecutive game while he recovers from a hamstring injury. Head coach Todd Bowles said Godwin, as well as fellow wideout Julio Jones and tackle Donovan Smith, will be game-time decisions for the Sunday night bout with the Kansas City Chiefs. Receiver Breshad Perriman is doubtful to play.
Panthers injuries: RB Christian McCaffrey questionable
McCaffrey popped up on the injury report this week after missing practice on Wednesday and Thursday with a thigh injury. He practiced Friday, but the Panthers listed him as questionable and head coach Matt Rhule said he is "very hopeful" McCaffrey will play against the Arizona Cardinals.
The hope for the Panthers today is that RB Christian McCaffrey (quad) practices at least on a limited basis and can attempt to play on Sunday, per league source.
— David Newton (@DNewtonespn) September 30, 2022
Falcons injuries: RB Cordarrelle Patterson questionable
Patterson reportedly returned to practice Friday after missing the previous two days with a knee injury. The team listed him as questionable for Week 4. Veteran Damien Williams or rookie Tyler Allgeier would be the next in line for touches if Patterson can't play.
Vikings injuries: RB Dalvin Cook expected to play with shoulder injury
Dalvin Cook was not listed on the Vikings' injury report ahead of the team's Week 4 match with the Saints in London despite suffering a shoulder injury in Week 3. He practiced fully on Thursday after missing Wednesday's practice and is "excited about the opportunity this week," head coach Kevin O'Connell said.
Browns injuries: Myles Garrett a game-time decision after car crash
Garrett has a chance to suit up in Week 4 just a few days after he was involved in a car accident on Monday. Garrett burst a blood vessel in his left eye and suffered injuries to his shoulder and biceps. He did not practice all week and is listed as questionable for the game against the Falcons.