Between them, the two sides have won the competition 13 times and have faced each other in two finals, most memorably in Istanbul in 2005, when Liverpool came from 3-0 down to win on penalties.
While Liverpool have been Champions League regulars in recent years, winning the competition in 2019 and reaching the final the year before, Milan are making their return to the tournament having not qualified since the 2013/14 season.
Date, kick-off time and venue
Liverpool vs AC Milan is scheduled for an 8pm BST kick-off at Anfield this evening.
Where to watch Liverpool vs AC Milan
TV channel: Tonight’s match will be televised on BT Sport 2, coverage starting at 7pm.
Live stream: BT Sport subscribers will be able to watch the match online via the website or BT Sport app.
Liverpool vs AC Milan team news
Liverpool will be without youngster Harvey Elliott for an extended period after the midfielder suffered a horrific leg injury in Sunday’s victory over Leeds, while Roberto Firmino remains out injured.
Olivier Giroud could make a swift return to England following his departure from Chelsea this summer, having returned from a Covid-enforced absence but Zlatan Ibrahimovic has been ruled out as he manages an Achilles issue.
Liverpool vs AC Milan prediction
On the first European night at Anfield with a crowd since the now infamous clash with Atletico Madrid as the coronavirus pandemic was first taking hold in the UK, Liverpool will surely be spurred to victory in this clash between historically two heavyweights.
Liverpool to win 2-0.
Head to head (h2h) history and results
Liverpool wins: 0
AC Milan wins: 1
Betting odds and tips
Liverpool to win: 40/85
AC Milan to win: 9/2
Odds via Betfair (subject to change). Click here to find out more.