The Seagulls will be hoping he can keep the early season momentum going that the team managed to achieve with the now-Chelsea boss, as they sit fourth in the Premier League table - four places and four points ahead of their weekend opponents.
Jurgen Klopp’s side have only played once since their dreadful defeat to Napoli on 7 September, while Brighton haven’t featured in any game at all since three days prior to that.
Interest will be high to see how De Zerbi sets out his team, while Liverpool are searching for better fluidity and energy in their game after a bad start to the season.
Here’s everything you need to know ahead of the match.
When is Liverpool vs Brighton?
The game will kick off at 3pm BST on Saturday 1 October at Anfield.
Where can I watch it?
This fixture is not scheduled for broadcast on UK TV. Highlights will be shown on Match of the Day from 10:25pm on BBC One.
Liverpool XI: Alisson, Alexander-Arnold, Matip, Van Dijk, Tsimikas, Fabinho, Henderson, Thiago, Carvalho, Salah, Firmino
Brighton XI: Sanchez, Veltman, Dunk, Webster, Estupinan, Caicedo, Mac Allister, Trossard, Gross, March, Welbeck
A game which could go in any direction at all, particularly depending on which version of the hosts turns up. Assuming they are firing and energetic, they should take the points. Liverpool 3-1 Brighton.