Anfield hosts Jesse Marsch’s Whites with the American boss under a huge amount of pressure, having failed to oversee a Premier League win since August.
Liverpool, meanwhile, lost to bottom club Nottingham Forest a week ago but bounced back to defeat Ajax ahead of this meeting.
Jurgen Klopp’s Reds have smashed 14 goals past Leeds in their four meetings since the Yorkshire side returned to the top flight just over two years’ ago - and their last win at Anfield came in April 2001.
Where to watch Liverpool vs Leeds
TV channel: The match will be televised on Sky Sports Main Event and Premier League, with coverage starting at 7.30pm before a 7.45pm BST kick-off.
Live stream: Sky Sports subscribers will be able to watch the match online via the Sky Go app.
Live blog: You can follow all the action via Standard Sport’s live blog.