The Reds are unbeaten in their last 67 league matches at home, but United possess the best away record in the division.
United have assumed top spot in the league after winning at Burnley on Tuesday, and they will be aiming to compound Liverpool’s poor run of form and move six points ahead in the table.
Jurgen Klopp’s side lost against Southampton in their last Premier League fixture and have failed to score in their previous two league games, but they defeated Aston Villa in the FA Cup last time out.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4:30pm GMT at Anfield.
How can I watch it?
The match is live on Sky Sports Premier League, with coverage starting from 4pm GMT.
What is the team news?
Jurgen Klopp will assess Joel Matip prior to kick-off, with Nat Phillips and Rhys Williams waiting in the wings should the Cameroonian defender miss out. Naby Keita is still out with a muscle problem.
Ole Gunnar Solskjaer will use Saturday’s training session to see which players are fit to play, with Anthony Martial suffering a light hamstring issue against Burnley. Brandon Williams and Phil Jones are out.
Liverpool XI: Alisson; Alexander-Arnold, Henderson, Fabinho, Robertson; Thiago, Wijnaldum; Shaqiri, Firmino, Mane; Salah
Man United XI: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Rashford, Fernandes, Pogba; Martial
Manchester United: 13/5
This is the biggest Premier League fixture of the season so far, and it could go either way – one moment of brilliance by any of the individual superstars could win the game for their respective club. However, I think it could be quite scrappy as neither side wants to lose, and they settle for a draw. 1-1.