The fierce rivals hold the top two places in the league, with the Red Devils three points clear at the top.
After defeat at Southampton, Klopp questioned why United receive so many penalties – and he has been criticised for doing so.
Meanwhile, United manager Ole Gunnar Solskjaer is remaining calm about his team's situation heading into the top-of-the-table clash.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4:30pm GMT at Anfield.
How can I watch it?
The match is live on Sky Sports Premier League, with coverage starting from 4pm GMT.
Liverpool: Alisson; Alexander-Arnold, Henderson, Fabinho, Robertson; Thiago, Wijnaldum; Shaqiri, Firmino, Mane; Salah
Manchester United: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Rashford, Fernandes, Pogba; Martial
Manchester United: 13/5
This is the biggest Premier League fixture of the season so far, and it could go either way – one moment of brilliance by any of the individual superstars could win the game for their respective club. However, I think it could be quite scrappy as neither side wants to lose, and they settle for a draw. 1-1.