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City opened up a four-point lead at the top with their 7-0 victory over Leeds on Tuesday and Jurgen Klopp’s side will be confident of a big win of their own against a Newcastle side deep in relegation trouble.
Newcastle lost 4-0 at Leicester on Sunday and face a nightmare run over the Christmas period as they face Liverpool, Manchester City and Manchester United in their next three games.
Liverpool have won seven straight games in all competitions since losing 3-2 to West Ham at the start of November.
How to watch Liverpool vs Newcastle
TV channel: The match will be televised on BT Sport 1. Coverage begins at 7pm GMT with kick-off at 8pm.
Live stream: BT Sport subscribers will be able to watch the match online via the website or BT Sport app.
Live blog: Keep up to date with all the action with Standard Sport’s up-to-the-minute LIVE blog.