After an inconsistent season, the German rotated his squad against Wolves at Molineux last time out, with the Reds kept at least one avenue for silverware open.
Klopp has previous in throwing young players in against Chelsea, starting Harvey Elliott against the Blues at Anfield last season.
Elliott scored the winner against Wolves and starts once more, while impressive young midfielder Stefan Bajcetic is also in the side alongside Naby Keita and Thiago.
James Milner starts at right-back with Alexander-Arnold among the substitutes, with Elliott in the front three as Nunez also misses out.
Joe Gomez and Ibrahima Konate are the centre-back pairing with Virgil van Dijk once again absent.
Liverpool XI: Alisson, Milner, Gomez, Konate, Robertson, Keita, Bajcetic, Thiago, Salah, Gakpo, Elliott
Subs: Kelleher, Fabinho, Henderson, Alexander-Arnold, Oxlade-Chamberlain, Tsimikas, Jones, Matip, Nunez
Date and time: Saturday 21 January 2023
TV channel and live stream: BT Sport