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Clyne has left the club’s summer tour of the United States and flown back to the UK for an operation after receiving the diagnosis.
The 28-year-old was hurt in Liverpool’s first tour match against Borussia Dortmund in South Bend, but the extent of the damage was not realised until days later. Clyne was with the squad in Boston where the reduced swelling exposed the serious damage.
As the rest of the Liverpool touring party arrived in New York on Monday evening, Clyne was returning to Merseyside.
Despite the anticipated lengthy absence, Liverpool are optimistic Clyne will play again this season although it is particularly inopportune time for the right-back to be absent.
He has one year remaining on his contract and Liverpool were in talks with several clubs about a possible transfer. Crystal Palace were eager to re-sign the player, who started his career at Selhurst Park.
A summer move now seems dead as he begins his rehabilitation, although Liverpool say he nature of the injury means it is not as bad as it could have been.
Such injuries often rule a player out for up to nine months, but in this case Liverpool do not think Clyne will be unavailable for so long.
Clyne moved to Liverpool on a five-year deal from Southampton for £12 million in 2015. He missed most of the 2017-18 with a persistent back injury during which time Trent Alexander-Arnold established himself in the right-back role.
Bournemouth took Clyne on loan for the second half of last season and he was considering several options before his latest bad luck struck.
Liverpool play their final tour match in the USA against Sporting Lisbon at Yankee Stadium on Wednesday night.