Hugo Lloris and Theo Hernandez have withdrawn from the France squad for this week's Nations League matches with Austria and Denmark.
France are already without a number of key players for the double-header, with Paul Pogba, N'Golo Kante, Karim Benzema, Lucas Hernandez and Kingsley Coman all sidelined.
Adrien Rabiot withdrew from the squad last week and Didier Deschamps is now without two more players for the visit of Austria on Thursday and trip to Denmark three days later.
France confirmed on Monday that Tottenham goalkeeper Lloris and Milan defender Theo Hernandez are nursing thigh and groin injuries respectively.
Nantes keeper Alban Lafont has earned a first call-up to provide cover for captain Lloris, while Aston Villa's Lucas Digne has been summoned as Theo Hernandez's replacement.
France have posted two draws and two defeats in their opening four Group A1 matches and are battling relegation from the top tier.