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London will host MLB regular-season games in three of the next four years, it was announced on Monday.
The New York Yankees and Boston Red Sox contested the first two MLB games played in Europe at the London Stadium in June 2019 as part of a two-year agreement, though the 2020 edition was cancelled due to the COVID-19 pandemic.
However, baseball will return to the capital of the United Kingdom next year, with further matches planned to take place in 2024 and 2026.
"All aspects of the inaugural MLB games in London were an overwhelming success," said league commissioner Rob Manfred.
"It was clear that sports fans in London had a great appetite for baseball and that passion was shared by mayor [Sadiq] Khan as well as the business and media community.
"We are confident in making a long-term commitment to London and are looking forward to returning to the city with more MLB games, special fan events, and other opportunities to play and watch the game."
Khan added: "Today is an historic day for London and baseball. I want to continue attracting world-class sport to our city as part of my mission to make London the sporting capital of the world.
"This long-term partnership with Major League Baseball is ambitious and includes regular-season games as well as a legacy programme, designed to grow the number of Londoners watching and playing baseball at a grassroots level.
"These games will be a fantastic opportunity to once again showcase the London Stadium as a multi-use venue and a fantastic asset for the capital."