Irish welcome back Terrence Hepetema from injury at inside centre, while Marcel van der Merwe starts at tighthead and Steve Mafi at lock.
While Irish have two tight defeats and a draw to start the season, Leicester have won all three matches.
“Tigers are looking good at the moment; they have three wins from three games,” said the young Exiles star Ollie Hassell-Collins.
“They have changed their direction recently, but we know what to expect. The squad are looking forward to Saturday when they come to our house, and we are excited for the challenge.”