The 21-year-old was the unlucky member of Britain’s leading trio of fly swimmers in the 100m on Sunday as Ellen Gandy and Fran Halsall booked their places in London.
But she showed no ill-effects of that disappointment as she cruised to a 2:10.01, more than half a second clear of Gandy who came home second of the Brits.
And Lowe revealed she felt comfortable ahead of a likely second showdown with Gandy in the final tomorrow.
She said: “I just try to relax in situations like this. It’s job done in the heats. I’ve now got the semi tonight and I’m just focusing on that.
“I’m pretty confident about getting to the final. As long as I don’t fall at the start I should be fine.
“The main challenge will come from Ellen [Gandy]. We will be battling it out.”
In the morning’s first event Grant Turner made an impressive entrance to the competition as he sprinted to a 49.69 in the 100m freestyle to qualify first for tonight’s semi-final.
He will face tough competition from reigning British champion Adam Brown and British record holder Simon Burnett who also safely made their way through the heats.
Turner said: “I’ve just been sitting at home and watching it on TV feeling pumped so I just wanted to get here and soak it all up.”
Meanwhile in the 200m breaststroke Andrew Willis edged Michael Jamieson to qualify quickest in 2:13.89, with British record holder Kris Gilchrist a little off the pace as he only got through in ninth.
There were also two British records in the multi classification events as David Ellis broke the S13 barrier for the 100m freestyle.
The City of Manchester swimmer touched home in 56.59 while Hannah Russell did the same in the women’s 100m freestyle to break her own S12 category record in 1:03.11.