Now it is a more familiar environment awaiting them with Groupama Stadium hosting a key domestic clash, which finished 1-1 between Lyon and PSG last season.
PSG topped the table going into the weekend with six wins from seven games while their opponents have recently been hit by back-to-back defeats.
Here are all the details for tuning in...
Where to watch Lyon vs PSG
TV channel: In th UK, the game will be broadcast live on BT Sport 2, with coverage starting at 7.15pm BST ahead of a 7.45pm kick-off.
Live stream: BT Sport subscribers can tune in via the BT Sport website or app.