It is the first time a selection has been made exclusively by players, with the most recognised All-Pro team being the one generated by votes from NFL writers and broadcasters, organised by the Associated Press.
NFLPA president J.C. Tretter issued a statement on Tuesday outlining why he felt it was important for players to have their say.
"For the first time ever, NFL players are honouring the best in the game by naming our Players' All-Pro team," he said. "Every active NFL player had the opportunity to cast their vote to decide who is really the best at each position.
"We compete against each other all season long, watching hours and hours of film week after week after week, and yet we have never had an opportunity to truly use our expertise to select the best of us.
"We think it is important that players take the time to define ourselves, because so far, we have allowed everyone else to either pick or dilute our voices."
The team was unveiled on Wednesday, with selections including Kansas City Chiefs quarterback Mahomes, Las Vegas Raiders running back Josh Jacobs, and his team-mate Davante Adams and Minnesota Vikings' star Jefferson as wide receivers.
The Chiefs and the San Francisco 49ers were the best represented teams, with four players each.
2022 Players' All-Pro Team – Quarterback: Patrick Mahomes (Kansas City Chiefs), Running back: Josh Jacobs (Las Vegas Raiders), Fullback: Kyle Juszczyk (San Francisco 49ers), Wide receivers: Justin Jefferson (Minnesota Vikings), Davante Adams (Las Vegas Raiders), Tight end: Travis Kelce (Kansas City Chiefs), Left tackle: Trent Williams (San Francisco 49ers), Left guard: Joel Bitonio (Cleveland Browns), Center: Jason Kelce (Philadelphia Eagles), Right guard: Zack Martin (Dallas Cowboys), Right tackle: Lane Johnson (Philadelphia Eagles), Edge rushers: Nick Bosa (San Francisco 49ers), Myles Garrett (Cleveland Browns), Interior defensive linemen: Chris Jones (Kansas City Chiefs), Aaron Donald (Los Angeles Rams), Nose tackle: Dexter Lawrence (New York Giants), Off-ball linebackers: Fred Warner (San Francisco 49ers), Roquan Smith (Baltimore Ravens), Cornerbacks: Pat Surtain II (Denver Broncos), Darius Slay (Philadelphia Eagles), Free safety: Minkah Fitzpatrick (Pittsburgh Steelers), Strong safety: Derwin James Jr (Los Angeles Chargers), Kick returner: Cordarrelle Patterson (Atlanta Falcons), Punt returner: KaVontae Turpin (Dallas Cowboys), Core teamers: Jeremy Reaves (Washington Commanders), Justin Hardee (New York Jets), Kicker: Jason Myers (Seattle Seahawks), Punter: Tommy Townsend (Kansas City Chiefs), Long snapper: Morgan Cox (Tennessee Titans).