Julian Nagelsmann's side are now seven points adrift of league leaders Bayern Munich after being held to a 1-1 draw at home to Freiburg.
But with the reigning champions and Borussia Dortmund meeting mid-week, there should be opportunity to close the gap.
But Leipzig cannot afford to drop more points and will hope to shake off a bit of ring rust when they take on Mainz - who resumed their campaign with a 2-2 draw away to Koln last Sunday.
Date, kick-off time and venue
The match kicks off at 2:30pm BST at the Opel Arena on Sunday, May 24.
Mainz 1-2 Leipzig: Of the two sides it was Leizpig who looked the far rustier as the season resumed last weekend. But with another week of training under their belts you expect them to look a little sharper this time out.
Timo Werner had a solid afternoon against Freiburg without looking too threatening in front of goal - a slicker performance should create those opportunities for him.
Live stream, TV channel and how to watch
BT Sport will be showing every game live on TV and online this weekend.
Mainz vs Leipzig will be shown on BT Sport 1HD from 2pm BST.
All the highlights from the game will also be shown during BT's Bundesliga Goals Show, which starts at 2:30pm on BT Sport Extra 3HD.
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