Two crews from Ballymoney and Coleraine fire stations attended the incident in the early hours of Saturday morning at a semi-detached house on Coleraine Road, Ballymoney, and rescued two people in their 70's.
Despite the best efforts by the Northern Ireland Ambulance Service and firefighters, a man in his 70's tragically died at the scene.
The fire was extinguished and crews left the incident in the town at 04:29am.
The cause of the fire is under investigation, but NIFRS believe it was an accidental fire.
Alan O’Neill, Group Commander, of the Fire Service said: “The thoughts and sympathies of Northern Ireland Fire and Rescue Service are with the loved ones of a man who has sadly died following a house fire in Ballymoney yesterday morning.”