But they take on one of the form teams in the division this afternoon, with David Moyes’ players having won seven of their last nine games, seeing off rivals Tottenham in their last fixture to climb back to fourth in the table.
West Ham’s unlikely assault on the Champions League spots takes the pressure off them somewhat as they head to Manchester with a free hit against one of the best sides in Europe.
Here’s all you need to know about the Premier League clash.
When is it?
The match will kick off at 12.30pm GMT this afternoon.
How can I watch it?
The game will air live on BT Sport 1. Subscribers can also stream it live on the BT Sport website and app.
What is the team news?
The injured Nathan Ake will miss out for City again in defence, but Guardiola has no other injury concerns, with Sergio Aguero having come off the bench against Borussia Monchengladbach earlier this week as he returned from his latest fitness setback.
West Ham are still without defenders Arthur Masuaku, Angelo Ogbonna and Andriy Yarmolenko, but they are otherwise in good health.
Man City XI: Ederson, Walker, Dias, Stones, Zinchenko, Gundogan, Fernandinho, Mahrez, De Bruyne, Torres, Aguero
West Ham XI: Randolph, Johnson, Coufal, Dawson, Diop, Cresswell, Soucek, Rice, Lingard, Fornals, Antonio
Man City: 2/9
West Ham: 11/1
West Ham are in terrific form and have nothing to lose here, but City are a juggernaut right now and the Hammers are likely to become nails this afternoon. Man City 2-0 West Ham.