It is Erik ten Hag’s only change from the win at Leicester, as Anthony Elanga makes way.
Antony went on strike to force through an £84million move from Ajax, meaning he hasn't played in three weeks, but starts against a Gunners side who are yet to drop points this season.
Elsewhere, Casemiro is still waiting for his first start and again is alongside Cristiano Ronaldo and captain Harry Maguire on the bench.
The Portuguese talisman, who failed to engineer a desired move away from the club during the summer, had been dropped after returning back late from pre-season.
Victor Lindelof is also on the bench while Anthony Martial again misses out with an Achilles problem.
Confirmed team news
Man United: de Gea, Dalot, Varane, Martinez, Malacia, McTominay, Eriksen, Antony, Bruno Fernandes, Sancho, Rashford
Subs: Dubravka, Lindelof, Maguire, Ronaldo, Fred, Casemiro, Heaton, Shaw, Elanga
Arsenal: Ramsdale, White, Saliba, Gabriel, Zinchenko, Sambi Lokonga, Xhaka, Saka, Odegaard, Martinelli, Jesus
Subs: Tierney, Smith Rowe, Nketiah, Holding, Cedric, Tomiyasu, Vieira, Alencar, Turner
Injured: Martial (Achilles)
Date and time: 4.30pm BST, Sunday September 4 2022
Venue: Old Trafford
TV channel: Sky Sports
Referee: Paul Tierney, Lee Mason (VAR)