The Brazilian international and Ronaldo have lifted 10 Champions League titles between them and both play in Europe’s secondary competition for the very first time.
Indeed, Casemiro is still getting up to speed following his high-profile £70million summer move from Real Madrid, while Ronaldo has been relegated to a bench role under Erik ten Hag.
Anthony Martial is still injured, while Luke Shaw misses out again as Tyrell Malacia starts at left-back.
Martin Dubravka has to wait to make his debut for the club in goal as David de Gea gets the nod, while Antony continues in attack, having scored on his debut against Arsenal.
The likes of Lisandro Martinez, Aaron Wan-Bissaka and Donny van de Beek miss out, with Brandon Williams and Facundo Pellistri also sidelined.
Man United XI: De Gea, Dalot, Lindelof, Maguire, Malacia, Fred, Casemiro, Eriksen, Antony, Elanga, Ronaldo
Subs: Dubravka, Heaton, Fredericson, Martinez, Varane, Wan-Bisaaka, Fernandes, Iqbal, McTominay, Sancho, Garnacho, McNeill