Manchester United have confirmed that Zlatan Ibrahimovic and Marcos Rojo will miss the remainder of the season after both suffering cruciate knee injuries.
Both men were stretched off during the extra-time Europa League victory over Anderlecht on Thursday night as United reached the last four of the competition.
Ibrahimovic landed awkwardly when challenging for the ball and as a result may have played his last game for the club, as his contract expires in the summer.
There is a one-year extension on the table for the striker, who has scored 28 goals this season at the age of 35, but he has been linked with a move to LA Galaxy.
Rojo was carried off with a similar injury after colliding with an Anderlecht player after only 23 minutes of the quarter-final second leg and leaves Jose Mourinho with a centre-back crisis.
United already have Phil Jones and Chris Smalling on the sidelines and Rojo’s injury leaves Eric Bailly and Daley Blind as the only fit centre-backs ahead of Thursday’s Manchester derby with Pep Guardiola’s City.