Manchester United have suffered another huge injury blow with Lisandro Martínez facing around 10 weeks out after aggravating the foot injury he suffered towards the end of last season.
Martínez missed the final seven and a half weeks of last season after suffering a broken metatarsal in his right foot in April.
The Argentina centre-half returned to action in pre-season but he aggravated the problem during the 3-1 defeat at Arsenal earlier this month and is now facing another long lay-off.
But the injury is severe enough that Martínez needs an extended spell on the sidelines in a fresh defensive blow to United manager Erik ten Hag.
Martínez requires further assessment but he is expected to be out for a similar length of time to the original injury.
A 10-week absence would mean Martínez missing the next 10 Premier League matches plus four Champions League group games and the League Cup fourth-round tie at home to Newcastle.
Left-back Sergio Reguilón, who missed the Carabao Cup win over Crystal Palace on Tuesday, will also be missing with a minor injury this weekend when United again face Roy Hodgson’s side, this time in the Premier League game.