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United have dropped to seventh in the table but they can move to within four points of fourth-placed Arsenal with a win.
Failure to beat a struggling Burnley side will mean United are outside the top six at the turn of the year for the first time since the 1989-90 season.
Burnley are 18th and will finish 2021 in the bottom three unless they can record a shock win at Old Trafford. Their last three matches have been postponed due to Covid, meaning this is the first time the Clarets have played since December 12.
Where to watch Man United vs Burnley
TV channel: The game, kicking off at 8.15pm, will be broadcast on Amazon Prime Video streaming.
Live stream: Amazon Prime subscribers will be able to watch the game through the Amazon Prime website or their app.
LIVE coverage: Get minute-by-minute updates through Standard Sport’s LIVE blog.