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Ole Gunnar Solskjaer’s team are experiencing a strong run of form that have seen United win each of their last four games in all competitions.
Premier League wins over Brighton and Spurs meshed with wins over Granada at home and abroad to take United into the Europa League semi-finals.
Meanwhile, Burnley are hoping for a positive result after successive league defeats at the hands of Southampton and Newcastle.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4pm GMT at Old Trafford.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 3:30pm GMT.
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, Pogba, Rashford
Burnley: Peacock-Farrell, Lowton, Tarkowski, Mee, Taylor, Gudmundsson, Brownhill, Westwood, Cork, McNeil, Wood
Manchester United: 4/11
Manchester United are in dangerous form and I think they could get a few goals against Burnley, who have lost their way a little recently. 3-0 Manchester United.