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The Red Devils have won their last four matches in all competitions, including victories in either leg in their Europa League tie with Granada.
Burnley are in poor form ahead of their short trip to Manchester, losing successive league matches against Southampton and Newcastle.
Sean Dyche’s side have impressed when visiting several big teams this season and may fancy their chances at the Theatre of Dreams.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4pm GMT at Old Trafford.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 3:30pm GMT.
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, Pogba, Rashford
Burnley: Peacock-Farrell, Lowton, Tarkowski, Mee, Taylor, Gudmundsson, Brownhill, Westwood, Cork, McNeil, Wood
Manchester United: 4/11
Manchester United are in dangerous form and I think they could get a few goals against Burnley, who have lost their way a little recently. 3-0 Manchester United.