A 3-0 win over Bournemouth has Erik ten Hag's team flying high heading into the cup competition with a sixth consecutive win, while Everton were humbled 4-1 at home to Brighton in a miserable display.
Ten Hag is, among other targets this season, looking to end United's six-year FA Cup trophy drought, and beating fellow manager Frank Lampard - who may not even see out the month at Goodison Park - would be the first hurdle cleared.
Where to watch Manchester United vs Everton
TV channel: In the UK, the match will be televised live and free-to-air on ITV1, with coverage starting at 7.30pm GMT ahead of an 8pm kick-off.
Live stream: Fans can also catch the game live online via the ITVX website and app.
Live blog: You can follow all the action via Standard Sport’s live blog.