Erik ten Hag has overseen eight consecutive victories, and just one defeat in 18, while City, while still sitting second in the league, continue to toil through games, culminating in a lifeless Carabao Cup elimination.
Pep Guardiola says the champions "know exactly what we have to do to play better" but there are currently few places tougher than the Theatre of Dreams, especially with the expected hostile atmosphere.
Here are all the details...
Date, kick-off time and venue
Manchester United vs Man City is scheduled for a 12.30pm GMT kick-off today, Saturday, January 14, 2023.
The match will take place at Old Trafford in Salford.
Where to watch Manchester United vs Man City
TV channel: In the UK, the match will be televised live on BT Sport.
Live stream: Fans can also catch the game live online via the BT Sport app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.
Manchester United vs Man City team news
Manchester United XI: De Gea; Wan-Bissaka, Varane, Shaw, Malacia; Casemiro, Fred; Eriksen, Fernandes, Rashford; Martial.
Subs: Heaton, Lindelof, Maguire, Martinez, Mainoo, McTominay, Elanga, Antony, Garnacho.
Manchester City XI: Ederson; Walker, Akanji, Ake, Cancelo; Rodri, De Bruyne, Bernardo; Mahrez, Foden, Haaland.
Subs: Ortega, Phillips, Gundogan, Grealish, Laporte, Alvarez, Gomez, Palmer, Lewis.
Manchester United vs Man City prediction
Manchester United are looking for their ninth victory on the bounce, while Manchester City are recovering from what some have described as their worst performance under Pep Guardiola as Southampton knocked them out of the Carabao Cup.
So the momentum is with the hosts but I expect the visitors to step up and provide a reaction to their midweek loss. Erling Haaland and Kevin De Bruyne will return, as mentioned above, and can prove the difference in any game.
Honours even at Old Trafford, 2-2 draw.
Head to head (h2h) history and results
City have won the last three Manchester derbies while scoring 12 goals.
Man United wins: 77
Man City wins: 58
Manchester United vs Man City match odds
Man United: 29/10
Man City: 10/11
Odds via Betfair (subject to change).