Ole Gunnar Solskjaer’s team selection drew criticism at the weekend, as he changed shape and saw his side lose in the FA Cup semi-final to Chelsea.
Only goals scored has United behind Leicester and out of the top four at present, so even a draw here puts it back in their own hands for Champions League football.
West Ham need a point to guarantee survival, but realistically they are already safe thanks to a superior goal difference.
Here’s everything you need to know about the game.
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When is the game?
The match kicks off at 6pm on Wednesday, 22 July at Old Trafford.
How can I watch the game online and on TV?
The game will be available to watch live on Sky Sports Premier League, Sky Sports Main Event and Sky Sports Ultra HD.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
Manchester United are missing a quartet of defenders, with Eric Bailly joining Luke Shaw, Phil Jones and Axel Tuanzebe on the sidelines.
For West Ham it’s just the two who have been absent in recent games, with Ryan Fredericks and Robert Snodgrass out.
Manchester United: De Gea, Fosu-Mensah, Lindelof, Maguire, Williams, Matic, Pogba, Fernandes, Greenwood, Rashford, Martial.
West Ham United: Fabianski, Johnson, Diop, Ogbonna, Cresswell, Rice, Soucek, Noble, Bowen, Fornals, Antonio.
West Ham are almost safe, with only a huge swing in goal difference now a threat to their survival. By contrast, the pressure is on United to keep winning and stay in the running for a Champions League spot.
Man United 2-1 West Ham