Both Antony and Anthony Martial make the XI, the Frenchman having been forced off during the second half of the 3-0 win over Bournemouth on Tuesday. Manager Erik ten Hag assured afterwards that the injury concern was not too serious.
Antony missed the win over Bournemouth but trained with the squad on Thursday ahead of tonight’s game.
Jadon Sancho misses out after Ten Hag stressed that he needs more time amid a mystery absence.
Donny van de Beek is sidelined after suffering what appeared to be a serious injury against the Cherries.
Lisandro Martinez is once again only on the bench with Luke Shaw at centre-back but Diogo Dalot is back to start after injury.
Jack Butland has joined on loan from Crystal Palace but is not in the squad.
Manchester United XI: De Gea; Dalot, Varane, Shaw, Malacia; Casemiro, Eriksen; Antony, Fernandes, Rashford; Martial.
Subs: Heaton, Lindelof, Maguire, Martinez, Wan-Bissaka, Fred, McTominay, Elanga, Garnacho.