A decision was made on the striker as he works his way back from several injuries earlier in the season, which was even more pressing after new signing Wout Weghorst was not registered in time for this game.
Lisandro Martinez is on the bench as Luke Shaw again partners Raphael Varane in defence.
Bruno Fernandes is available again after suspension and will line up alongside Christian Eriksen and the in-form Marcus Rashford.
Manchester United XI: De Gea; Wan-Bissaka, Varane, Shaw, Malacia; Casemiro, Fred; Eriksen, Fernandes, Rashford; Martial.
Subs: Heaton, Lindelof, Maguire, Martinez, Mainoo, McTominay, Elanga, Antony, Garnacho.