Wigan pair Hugo Rodallega and Shaun Maloney are hoping to be fit for Saturday's Barclays Premier League trip to Fulham.
Colombian forward Rodallega has been out for six weeks with a knee injury while Scottish midfielder Maloney, a key figure in recent weeks, missed Monday's win at Arsenal with his own knee problem.
Manager Roberto Martinez said: "With Hugo we are getting closer, it is too early to tell if he is going to be ready for Saturday but he is progressing really well. It is similar for Shaun Maloney, who is 50-50 for the weekend."
Spanish midfielder Albert Crusat is definitely missing having been ruled out for up to two weeks with an injury suffered in training.
Martinez said: "Albert, it has been confirmed, has a grade-one soft tissue problem in his calf, so he should be between 10-14 days. That is a real disappointment because Albert was hitting a really good moment of form.
"It is a little bit of a setback but we hope he is going to be available for the last two games of the season."
Wigan, in the bottom three for most of the campaign, have given themselves a strong chance of avoiding relegation with a series of outstanding results in the past month.
Victory at Arsenal took Latics five points clear of the drop zone with four games remaining and came after similarly impressive wins over Liverpool and Manchester United. Amid that fine run, Wigan have also beaten Stoke and suffered a controversial defeat to Chelsea.
Martinez said: "To have the mentality to go into these grounds and play against these sides with the eye-to-eye mentality, and being able to get the three points, is a fantastic achievement.
"Every player in this football club deserves huge credit. But we know we don't have enough points. We have 12 points to fight for and we need to make sure we keep the same approach."