Ruben Castro is doubtful with a knee problem for Betis, while Benat Etxebarria has been carrying a knock for several weeks. Defender Mario Alvarez has undergone surgery on a leg injury but is expected to miss the rest of the season.
Villarreal centre-back Cristian Zapata is suspended, with Gonzalo Rodriguez set to deputise. Coach Miguel Angel Lotina has hinted that Nilmar could start, saying: "The team needs him."
Betis are without a win in their last four matches against Villarreal in the top-flight (D1 L3).
Villarreal have scored in all nine of their top-flight visits to Betis.
Pepe Mel’s side are without a win in four league games at home (D3 L1), their joint-poorest run this season.
The Yellow Submarine have not won back-to-back away games in the top flight since September 2010.
Villarreal have only scored in six of their 15 league games on the road this season.
Villarreal are, along with Málaga, the only side yet to score in the first 15 minutes of an away match in La Liga this season.
At home, the side from Seville have conceded the most goals in the last 15 minutes of La Liga games this season (8).
The “Yellow Submarine” have dropped the most points thanks to goals conceded in the last 15 minutes of LigaBBVA matches this season (9).
Villarreal have conceded an average of 0.33 goals per game with Lotina on the bench in La Liga, compared to 1.43 under Garrido and 1.63 under Molina.
Real Betis 11/10, draw 23/10, Villarreal 5/2