Joan Mir has signed a two-year deal to become compatriot Marc Marquez's Repsol Honda team-mate.
Suzuki Ecstar rider Mir will join Marquez at Honda for the 2023 and 2024 MotoGP seasons.
The 24-year-old agreed to make the move after Suzuki confirmed this will be their last season competing in the premier class.
Mir, the 2020 MotoGP world champion, follows his team-mate Alex Rins in switching from Suzuki to Honda.
The Spaniard is relishing his next challenge and is determined to finishing this season strongly when he has recovered from an ankle injury that will keep him out of the San Marino Grand Prix this weekend.
He said: "I'm very excited to officially announce that I will join the Repsol Honda Team next year.
"Thanks to HRC for trusting me and giving me the opportunity to defend these historic colours, which are full of history and world titles.
"We will take advantage of all my experience accumulated over the years in MotoGP with Suzuki to contribute as much as possible to the project and to fight together to become world champions again.
"Now it's time to continue focused on my recovery to return to the circuits as soon as possible and have a great end of the season with Team Suzuki Ecstar."
Meanwhile, Aprilia Racing and RNF on Tuesday confirmed that Miguel Oliveira (Red Bull KTM Factory Racing) and Raul Fernandez (Tech3 KTM Factory Racing) will be racing RS-GPs next season in the Noale factory's new Independent Team.