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Sergio Aguero said it was the goal that "changed everything" as he returned to Manchester City on Friday for the unveiling of a statue to recognise his famous title-winning strike.
The Argentinian hit City's stoppage-time winner against QPR on May 13, 2012, earning a 3-2 win that delivered a first top-flight title for the club since the 1967-68 season.
It marked the beginning of a spell of dominance for City, who are on the cusp of achieving a sixth Premier League crown in 11 seasons.
Aguero, who went on to become City's record scorer, left the club at the end of last season to join Barcelona and has since retired after a heart condition was detected.
He was guest of honour at the Etihad Stadium as a statue in his likeness was revealed, a full 10 years to the day since the goal against QPR.
The 33-year-old described that as the standout goal of his career.
Speaking to Sky Sports News and BBC Sport, Aguero said of his latest honour: "For me, it is fantastic. I'm very happy for the statue. Now I'm enjoying it, you know.
"It's special. For me, that moment changed my life, it changed the club, everything. It's the best moment in my life. That moment will always be in my heart."
"We don't know what [would have] happened if we lost the Premier League that year, so that year changed everything."
When the Premier League asked its Twitter followers on Friday whether Aguero's goal was "the most iconic moment" in its 30-year history, Aguero replied to say, "Of course", adding a laughter emoji.