The first Champions League game of the season sees Jurgen Klopp take his side to the Diego Armando Maradona Stadium, where his team were beaten four years ago.
Thankfully for Klopp, there is some light at the end of the injury crisis tunnel at last, though Jordan Henderson will miss the game.
Darwin Nunez, who impressed against Liverpool for Benfica in this very competition, could make his European debut for the club.
Here’s everything you need to know about where to watch the game.
Where to watch Napoli vs Liverpool
TV channel: In the UK, tonight’s match will be televised live on BT Sport 2, with coverage beginning at 7pm BST ahead of an 8pm kick-off.
Live stream: BT Sport subscribers will also be able to watch the game online via the BT Sport website or app.
Live blog: You can follow all tonight’s action via Standard Sport’s live match blog.