More than 4,000 coronavirus cases have been detected over the past two weeks in Barcelona from around 30 outbreaks of the virus, raising concerns ahead of the European fixture on August 8.
"I call Uefa all the time, but it's shameful," Napoli president Aurelio De Laurentiis told media in Milan on Thursday.
"You hear about it in the big media [outlets] in Spain, but they aren't interested.
"How long will they wait before saying we will play in Portugal, Germany or Switzerland?"
Uefa are analysing all the second-leg fixtures and could consider a change of venue, although Catalan health authorities have assured that there is no risk in playing the game at Camp Nou as planned.
"It seems like we're at school," De Laurentiis added. "At Uefa, nobody knows how to do business, and with our money too.
"If they decided that the Champions League is to be played in Portugal and the Europa League in Germany, we could play there as well.
"I don't understand why we have to go to a city that, at this moment, has great problems."