Half of the Elite Eight is set as Oregon, Gonzaga, Kansas and Xavier advanced to the weekend.
The other four spots will be filled Friday as the Sweet16 concludes.
Friday's marquee matchup is in Memphis as Kentucky faces UCLAfor the second time this season.
Here's a look at Friday's Sweet 16 matchups:
No. 1 North Carolina vs. No. 4 Butler (7:09 p.m. ET on CBS)
TheTar Heels (29-7) barely escaped with a win over Arkansas to get to the Sweet 16 and will look to avoid the upset and remain the top seed in theSouth Region.
Butler's assists leader, Tyler Lewis, is familiar with the Tar Heels after facing them for two seasons while at N.C.State before transferring to Butler. He'll have to be the catalyst for the Bulldogs(25-8) if they're going to reach the Elite Eight for the first time since 2011.
Butler will have to slow the game while the Tar Heels, who average 85 points per game, will want to up the tempo. Butler will have its hands full with UNC's bevy of scorers in Justin Jackson, Joel Berry II, Kennedy Meeks andIsaiah Hicks.
No. 3 Baylor vs. No. 7 South Carolina (7:29 p.m. on TBS)
The Gamecocks (24-10) hope to continue their momentum after knocking off No. 2 Duke on Sunday. To advance to the Elite Eight for the first time in program history, South Carolina will have to pull off another upset.
Baylor (27-7) is the highestremaining seed in what is a wide-open East bracket.Johnathan Motley leads the Bears, averaging more than 17 points and nearly 10 rebounds per game. The 6-10 Motley could help Baylor control the paint. South Carolina has the edge in the backcourt with Sindarius Thornwell.
The senior guard is averaging more than 21 points per game and has scored 53 points through the first two NCAA Tourney games.
No. 2 Kentucky vs. No. 3 UCLA (9:39 p.m. on CBS)
A pair of blue bloods meet in the other half of the South Region as theWildcats (31-5) andBruins (31-4) tangle in Memphis. UCLA outlasted Kentucky in a 97-92 shootout in December. The Bruins had six players score in double digits, led byIsaac Hamilton's 19 points.
Hamilton averages 14 pointsbut has scored just 24 through two tourney wins. He's UCLA's fourth-leading scorer as T.J. Leaf, Bryce Alford and Lonzo Ball lead the way.
Malik Monk leads Kentucky with 20 points per game, but De'Aaron Fox has been on fire over the last month. The 6-3 guard could be the difference-maker ifKentucky is going to avenge its earlier loss and advance.
No. 4 Florida vs. No. 8 Wisconsin(9:59 p.m. on TBS)
Wisconsin seniors Bronson Koenig, Nigel Hayes and Zack Showalter can join an exclusive club with two more victories. Should the Badgers (27-9) beat Florida and then win again Sunday, the trio of senior starters would be among the few college basketball players to reach the Final Four three times.
The Gators (26-8) were most recently in the Final Four in 2014, when Wisconsin went as Koenig, Hayes and Showalter were freshmen. Both lost in the semifinals as Connecticut beat Kentucky for the championship.
The Badgers are among the best defensive teams in the country, soFlorida will have to get some productivity from leading scorer KeVaughn Allen, who has just 11 points over the last two games. Junior Devin Robinson has picked up the scoring slack for the Gators and his matchup with Hayes, who is also a 6-8 forward, could be the key.