The Netherlands will be without Frenkie de Jong, Memphis Depay and Teun Koopmeiners for their decisive Nations League showdown with Belgium on Sunday.
De Jong and Depay have been ruled out due to thigh and leg injuries respectively.
The Barcelona duo did the damage during a 2-0 away victory over Poland on Thursday and will play no part in the final Group A4 game versus the Red Devils at Johan Cruijff Arena
Atalanta midfielder Koopmeiners also misses out in Amsterdam after suffering a concussion.
Netherlands boss Louis van Gaal has called up Ajax's Brian Brobbey and Ryan Gravenberch of Bayern Munich in the absence of the trio.
The Dutch will qualify for the Nations League Finals if they avoid defeat by three goals or more.