Both Manuel Neuer and Leon Goretzka have been withdrawn from the Germany squad ahead of their two upcoming Nations League fixtures.
The Bayern Munich duo tested positive for COVID-19 on Wednesday and have since been in isolation and left the team hotel.
The German Football Association (DFB) stated: "Due to a positive coronavirus test within one of the players' private circles, the medical team conducted a rapid antigen test on the whole nation team.
"All members of the coaching staff and the team are required to test negative before travelling. Confirmed contact of both players will be tested daily."
Germany play Hungary on Friday and England on Monday, and coach Hansi Flick will no doubt feel the strain of missing such vital players from his squad.
Goalkeeper and captain Neuer has been replaced by Hoffenheim's Oliver Baumann, with Barcelona's Marc-Andre ter Stegen and Eintracht Frankfurt's Kevin Trapp counted among Flick's other options in goal.
The DFB was yet to confirm the identity of any additions in Goretzka's place, although Flick still has the likes of Joshua Kimmich, Ilkay Gundogan and Thomas Muller at his disposal.