Manuel Neuer and Lucas Hernandez were back in Bayern Munich training on Monday, with their respective hopes of being fit for the World Cup seemingly receiving a boost.
Bayern captain Neuer had been struggling with a shoulder injury that forced him to miss six games, but he returned to goalkeeper training ahead of Tuesday's Champions League clash with Inter.
As recently as last week Nagelsmann did not want to commit to Neuer being ready to feature for Germany at the World Cup, saying he is not a "mystic".
But he appears hopeful of being able to call upon the 36-year-old away to Hertha Berlin on Saturday.
"We hope he'll be available again for the weekend. He came through training well and didn't show any reaction. But we'll have to wait and see," Nagelsmann told reporters.
Tuesday's game will also come too soon for Hernandez, not that the match has much riding on it – Bayern and Inter are already confirmed as Group C winners and runners-up respectively.
However, the France international is close to a return to action after suffering an adductor tear in September, with Monday seeing him take part in full team training.
Thomas Muller remains sidelined for the time being as well.
The Germany attacker has struggled lately with a hip issue, and Nagelsmann accepts he may not even be available to face Hertha.
"We'll reduce Thomas's workload this week and see how things are for the weekend," Nagelsmann said.
"But I'm leaning more towards him not being back at the weekend."
Matthijs de Ligt is a new name to be added to the injury list for Tuesday with a minor knee injury, leaving Nagelsmann's squad down to its bare bones as they look to end the group stage with maximum points.
"We will have to rotate a bit because we have some injured players who shouldn't play more than 45 minutes," he added.
"Nevertheless, we want to win the game. Anyone can show themselves. It's still a Champions League game and 18 points would be nice."
However, Nagelsmann suggested he will not give chances to youngsters who do not deserve an opportunity as he bemoaned the Under-19s' Youth League elimination after winning none of their first five group games.
"We'll take everyone but we'll see [on Tuesday] whether [youngsters] get chances," he continued.
"In general, I'm a friend of the fact that you have to earn success. You have to develop your genes, which is particularly important for young players at FC Bayern Munich.
"Success is part of a good education. You're doomed to win here at the club, so it's a shame we were eliminated so early in the Youth League.
"At FC Bayern, you always have to be the best in the youth teams so that the step-up to the pros isn't so big."