Jurgen Klopp could rotate his squad to hand opportunities to some of his younger players.
While Steve Bruce will be hoping to secure some momentum heading into next season after comfortably guiding the Magpies to safety.
Mohamed Salah looks set to fall just short in the race for the Premier League golden boot, with Jamie Vardy four clear currently on 23 goals.
Here is our prediction for the game at St James’ Park.
When is it and what time is kick-off?
The match will begin at 4pm on Sunday 26 July at St James’ Park.
How can I watch it online and on TV?
The match will be broadcast live on BT Sport 2 and BT Sport Extra 2, you can find a live stream for the game through the BT Sport app to watch on mobile devices.
What is the team news?
Emil Krafth is a doubt with a knock to his ankle, which means the Swede could join Fabian Schar (shoulder), Paul Dummett (ineligible), Jamaal Lascelles (knock), Ciaran Clark (ankle) and Florian Lejeune (thigh) on the sidelines. Isaac Hayden (hamstring) and Sean Longstaff (hamstring) could return.
Joel Matip (foot) and Jordan Henderson (knee) remain out, while Dejan Lovren and Adam Lallana could be omitted with both primed for moves away. Takumi Minamino, Curtis Jones, Neco Williams and Harvey Elliott could all be in line for minutes in this free hit for the champions.
Newcastle XI: Dubravka, Manquillo, Fernandez, Rose, Ritchie, Bentaleb, Shelvey, Lazaro, Almiron, Saint-Maximin, Gayle
Liverpool XI: Alisson, Williams, Gomez, Van Dijk, Robertson, Milner, Keita, Wijnaldum, Oxlade-Chamberlain, Minamino, Origi
What are the odds?
The Reds may be nursing a few hangovers after the party following the trophy presentation, but they should have too much quality for an injury-hit Newcastle. Mohamed Salah is still hungry for goals and the Reds should ease to an emphatic victory to close off their historic campaign. 0-3.